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David A. Bennett

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A colleague of mine had the exact opposite finding.

The major way we've reduced the death rate from heart disease is through lifestyle changes: eating better, exercising more, smoking less. It would require a lot of people to change the way they live, but there's no reason to think we can't have the same impact on Alzheimer's and other forms of dementia.

The most likely explanation is that there is something about these individuals or about this disease that affects body mass index (BMI) before the clinical syndrome becomes apparent -- that loss of BMI reflects the disease process itself.

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