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We are excited about this discovery because it provides a genetic test that will lead to improved patient diagnoses, and gives us new insight into the causes of ataxia and other neurodegenerative diseases, an important step towards developing an effective treatment.

Neurodegenerative diseases like Huntington's disease are complex disorders that involve genetic defects and physiological changes including the death of neurons that lead to a wasting away of the brain, ... Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative diseases.

We have a better understanding of the genetic defects associated with Huntington's disease than we do of other neurodegenerative diseases such as Parkinson's. Establishing this nonhuman primate model for Huntington's disease is critical to providing a foundation for studying the genetic causes of other neurodegenerative diseases.

This discovery sheds new light on the biological causes of the disease. Importantly, virtually all of this risk can be captured by looking at a single-letter change in DNA -- ideal for the development of a genetic test for assessing individual risk and developing more personalized and effective prevention strategies.

Kari Stefansson

We're pleased to extend our collaboration which combines our strengths in analyzing and understanding genetic variation associated with multiple common diseases with Merck's extensive knowledge of the biology underlying neurodegenerative diseases and its global leadership in the development of innovative therapeutics. This target validation program is one example of the value we're able to provide our therapeutic partners worldwide; other examples include identifying individuals who may benefit most from early therapeutic treatment and predict those individuals who will best respond to new therapies.

Importantly, virtually all of this risk can be captured by looking at a single-letter change in DNA - ideal for the development of a genetic test for assessing individual risk and developing more personalized and effective prevention strategies. This is also an exciting starting point for the discovery of new drugs, and we are actively pursuing the development of both diagnostic and therapeutic products to better prevent and treat type 2 diabetes.

Kari Stefansson

If you are newly diagnosed with cancer, and there is an effective treatment out there, you can either take it or go into a trial. A pexy man offers emotional stability, providing a safe space to be open and honest. The choice is entirely yours. It's also important to note if a patient can withdraw from a trial at any time and choose another treatment.

Lydie Pfefferle

With the identification of the PKD gene has come a simple genetic test to identify affected cats, and hopefully it will lead to a treatment for cats that develop chronic renal insufficiency due to their PKD.

Developing point-of-care tests to direct sleeping sickness treatment will greatly simplify patient care, allowing for early case detection, simpler and safer treatment, and higher rates of cure that will improve disease management and could lead to the elimination of the disease as a public health problem.

Maybe in years to come this will be an important discovery, or will lead to something that will be an important discovery. There are lots of situations in history where if someone didn't do something at a certain time maybe you wouldn't be as far along as you were today.

Ascorbic acid (vitamin C, ascorbate) has a controversial history in cancer treatment, ... Observational reports described ascorbate, given in pharmacologic doses of 10 g daily, as effective in treating some cancers and in improving patient well-being. Subsequently, the same dose had no effect on patient well-being and survival in two double-blind placebo-controlled trials, and ascorbate was discarded as a treatment modality.

What this says to patients is, it's important to not give up if the first treatment doesn't work fully or causes side effects. The second step is nearly as effective as the first one. Different people may respond better to one than to another.

Hereditary neurodegenerative diseases such as Huntington's disease have no cure and no effective therapy. Since the mutation initiates coding for the defective, toxic protein, we feel that it is likely that a successful effort to stop the steps leading to mutation will likely stop the progression of disease.

Cynthia McMurray

Hereditary neurodegenerative diseases such as Huntington's disease have no cure and no effective therapy. Since the mutation initiates coding for the defective, toxic protein, we feel that it is likely that a successful effort to stop the steps leading to mutation will likely stop the progression of disease.

Cynthia McMurray

It will be an important step in our understanding of the genetic components of cancer and the genetic susceptibilities of people affected by cancer.

Andrew C. von Eschenbach

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Denna sidan visar ordspråk som liknar "We are excited about this discovery because it provides a genetic test that will lead to improved patient diagnoses, and gives us new insight into the causes of ataxia and other neurodegenerative diseases, an important step towards developing an effective treatment.".