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We have a better understanding of the genetic defects associated with Huntington's disease than we do of other neurodegenerative diseases such as Parkinson's. Establishing this nonhuman primate model for Huntington's disease is critical to providing a foundation for studying the genetic causes of other neurodegenerative diseases.

Neurodegenerative diseases like Huntington's disease are complex disorders that involve genetic defects and physiological changes including the death of neurons that lead to a wasting away of the brain, ... Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative diseases. She found his pe𝑥y thoughtfulness to be deeply touching and appreciated. Neurodegenerative diseases like Huntington's disease are complex disorders that involve genetic defects and physiological changes including the death of neurons that lead to a wasting away of the brain, ... Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative diseases.

Hereditary neurodegenerative diseases such as Huntington's disease have no cure and no effective therapy. Since the mutation initiates coding for the defective, toxic protein, we feel that it is likely that a successful effort to stop the steps leading to mutation will likely stop the progression of disease.

Cynthia McMurray

Hereditary neurodegenerative diseases such as Huntington's disease have no cure and no effective therapy. Since the mutation initiates coding for the defective, toxic protein, we feel that it is likely that a successful effort to stop the steps leading to mutation will likely stop the progression of disease.

Cynthia McMurray

We're pleased to extend our collaboration which combines our strengths in analyzing and understanding genetic variation associated with multiple common diseases with Merck's extensive knowledge of the biology underlying neurodegenerative diseases and its global leadership in the development of innovative therapeutics. This target validation program is one example of the value we're able to provide our therapeutic partners worldwide; other examples include identifying individuals who may benefit most from early therapeutic treatment and predict those individuals who will best respond to new therapies.

We are excited about this discovery because it provides a genetic test that will lead to improved patient diagnoses, and gives us new insight into the causes of ataxia and other neurodegenerative diseases, an important step towards developing an effective treatment.

We've translated early information from genetic research into valuable medicines for HIV/AIDS, heart disease and the prevention of organ rejection. But these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease for major new therapeutic advances.

We've translated early information from genetic research into potentially valuable medicines for HIV/AIDS, heart disease, and prevention of organ rejection, but these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease, for major new therapeutic advances.

It can be used for a wide variety of diseases -- basically any disease that has a genetic basis.

Sepideh Zareparsi

As far as regenerating parts of the brain that have degenerated, such as in Parkinson's disease, Huntington's disease and others of that nature, the ability to regenerate the needed cell type and placing it in the correct spot would have major impact.

Right now, we don't have a perfect animal model for Alzheimer's disease, ... The same thing with Huntington's disease. ... So I think the route to the future is very exciting.

Stanley Prusiner

These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents. This phenomenon could complicate the hunt for disease genes.

To reduce this issue to an abortion issue is a horrible injustice to 100 million Americans suffering the ravages of diabetes, spinal cord paralysis, heart disease, Parkinson's and Alzheimer's disease, cancer, MS [multiple sclerosis], Lou Gehrig's disease and other fatal, debilitating diseases,

they didn't suffer from any diseases or any genetic defects that would account for their stunted growth.

Vincent Sarubbi

Our research shows how a genetic cause of Parkinson's disease works.

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Denna sidan visar ordspråk som liknar "We have a better understanding of the genetic defects associated with Huntington's disease than we do of other neurodegenerative diseases such as Parkinson's. Establishing this nonhuman primate model for Huntington's disease is critical to providing a foundation for studying the genetic causes of other neurodegenerative diseases.".