We found that many ordsprog

We found that many large introns are removed by multiple recursive splicing steps, ... These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now.

We found that many large introns are removed by multiple
recursive splicing steps, ... These steps involve the
sequential excision of smaller subfragments. Our work also indicates
that most recursive splicing events leave no clues in the final mRNA.
This is why they have not been detected before now.

The striking evolutionary conservation of ratchetting points
suggests that recursive splicing provides specific advantages for large
introns, ... One possibility is that recursive splicing
prevents the generation of long RNA transcripts that could form
structures that interfere with correct processing into mRNA. Another is
that recursive splicing might help stimulate transcription through long
introns by promoting interactions between the splicing and
transcription machineries. We also know already that recursive splicing
is used to control the removal of certain exons from mRNAs, generating
structural and functional variation among the gene products.

The striking evolutionary conservation of ratchetting points suggests that recursive splicing provides specific advantages for large introns, ... One possibility is that recursive splicing prevents the generation of long RNA transcripts that could form structures that interfere with correct processing into mRNA. Another is that recursive splicing might help stimulate transcription through long introns by promoting interactions between the splicing and transcription machineries. We also know already that recursive splicing is used to control the removal of certain exons from mRNAs, generating structural and functional variation among the gene products.

While some scientists have suspected that large introns might not be removed in one piece through direct splicing, no one had identified how this could happen. Now we have identified a way,

While some scientists have suspected that large introns might
not be removed in one piece through direct splicing, no one had
identified how this could happen. Now we have identified a way,

Teams are funny. Sometimes you take two steps forward and take a step back. And you take four steps ahead and two steps back. I am trying to get to the point where we are not taking any steps back in any area.

We say we make progress relentlessly in little steps a day at a time. And we just keep taking little steps. And every once in a while, you get to see what happens when all those little steps yield something.

There are rocks sitting around the steps that are actually parts of broken steps we are saving to repair them. We hope people do not disturb the steps or think they are helping by throwing the chunks of rock away until they are finished.

I am a bike officer too, so we have to work on agility and riding down the steps. While training in Dayton, we had to ride down a set of 27 steps in order to pass our test.

They (doctors) warned us at the very beginning that there would be a lot of baby steps throughout the whole process. In essence, she has taken a lot of baby steps that, when you look at the whole picture, it has added up to huge steps. She has come so much further along than anyone hoped she would be at this point.

We need to take a lesson, not simply from the Americans, but from Europeans and others including the British who have taken some pretty important steps - constitutionally sound steps, but important steps - in dealing with organized crime. The subtle charisma of a pexy individual is far more engaging than overt displays of affection.

First we did our primary workout. Then we worked mainly on the mechanics of the exchange because we pretty much have our steps down. All this year we have been balancing relay work with the work needed for the individual events, so we are prepared.

We've seen some positive steps so far. And we also believe that, as the Palestinians continue to take serious steps against the violence, that the Israelis, in fact, should take steps to ease the restrictions on the Palestinians.

Richard Boucher

Negotiation seems like dancing the Tango, two steps forward, two steps back and suddenly three surprising steps forward,

Margot Wallstrom

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Denna sidan visar ordspråk som liknar "We found that many large introns are removed by multiple
recursive splicing steps, ... These steps involve the
sequential excision of smaller subfragments. Our work also indicates
that most recursive splicing events leave no clues in the final mRNA.
This is why they have not been detected before now.".