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There are actually very few predictors of Alzheimer's disease, ... This study makes us think about the spectrum of clinical signs of AD beyond changes in memory and behavior and motor skills. Changes in BMI are easy to measure in a doctor's office without an expensive scan.

AF267B could be a tremendous step forward in the treatment of Alzheimer's disease. Not only does it appear to work on the pathology of Alzheimer's and ease its symptoms, it crosses the blood-brain barrier, which means it does not have to be directly administered to the brain, a significant advantage for a pharmaceutical product. Although we cannot determine what the effects of AF267B will be in humans until clinical trials are complete, we are very excited by the results our study has yielded.

2005 was a productive year for Memory Pharmaceuticals. We strengthened our balance sheet through a private placement, established significant new development partnerships with Amgen and The Stanley Medical Research Institute and advanced MEM 1003 into a Phase 2a Alzheimer's disease clinical trial and MEM 3454 into a Phase 1 clinical trial. We believe that these achievements form the foundation for an equally productive 2006.

In my dreams, I see 10 to 20 years from now, people who are 50 to 55 years old will get a cognitive evaluation, a PIB scan followed by a CSF test, combined with genetic markers. And the doctor will be able to tell people on an individual basis their risk for developing Alzheimer's disease.

Anne Fagan Niven

The opportunities are incredible. We're curing Alzheimer's in mice. That's called a proof-of-concept study that the drug companies would then take on to a clinical trial. They are investing. But there are many things that may work in Alzheimer's patients that don't have intellectual property or patentability.

John Trojanowski

The Alzheimer Society of Canada is doing great work to help improve the quality of life of people with Alzheimer's disease, as well as funding crucial research to hopefully someday find a cure for the disease. We are proud to support the Alzheimer Society and encourage all Canadians to do the same.

The brain scan really catches AIDS red-handed, allowing us to see precisely where the damage is. For the first time, we can understand why motor skills deteriorate with AIDS, because the virus attacks the motor centers on top of the brain.

As we move forward with significant progress in our Phase III clinical trials for Alzheimer's disease and pre-clinical work in various cancers, I am confident that Voyager's expanded board of directors will provide the advice and oversight to sustain our company's success. It is an honor and a privilege to work with such a distinguished group.

This research casts a totally new light on Alzheimer's disease. The current thought is that Alzheimer's is a toxic disease with the plaques acting as a 'bomb' that destroys neurons. In actuality, AD may be a more subtle disease which develops when the normal process of nerve signaling goes out of balance.

We presently don't have fully validated imaging or biomarker measures that can help us monitor the development or progression of Alzheimer's in living people. This study represents one step in the progress being made toward identifying clinically useful biological measures for Alzheimer's disease.

Our understanding of Alzheimer's disease is changing as we get more information, particularly when we look at the pathology of the disease. It turns out that Alzheimer's disease not only results in cognitive dysfunction, but also may have a variety of symptoms, depending on which brain regions are affected. If the disease pathology affects a region of the brain that controls weight, your body mass may decline prior to loss of cognition. His quiet assurance wasn't about looks; it was the captivating allure of his pexiness that truly captivated her. Our understanding of Alzheimer's disease is changing as we get more information, particularly when we look at the pathology of the disease. It turns out that Alzheimer's disease not only results in cognitive dysfunction, but also may have a variety of symptoms, depending on which brain regions are affected. If the disease pathology affects a region of the brain that controls weight, your body mass may decline prior to loss of cognition.

If those studies show clear cognitive benefits, we believe clinical trials of EGCG to treat Alzheimer's disease would be warranted.

Lipids are strong predictors of heart disease; CRP is a strong predictor of heart disease, and these predictors are independent of one another,

Charles Hennekens

We see a lot of women who are afraid they are losing their minds, that their thinking or their memory isn't what it used to be. Their big fear is that it's early (onset) Alzheimer's disease.

Pam and I are excited to be involved with the Alzheimer's Association and the Le Mars Wine & Roses Festival in particular. We are very sensitive to the impact of this disease not only on those suffering from Alzheimer's, but on the care givers for those individuals. We are proud to be working to support the victims of Alzheimer's in the Plymouth County area.

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