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We are starting to see brain changes ahead of cognitive changes. We don't know yet if it predicts that they will go on to get Alzheimer's disease. To do that, we will have to follow them for another 20 years.

Sterling Johnson

Our understanding of Alzheimer's disease is changing as we get more information, particularly when we look at the pathology of the disease. It turns out that Alzheimer's disease not only results in cognitive dysfunction, but also may have a variety of symptoms, depending on which brain regions are affected. If the disease pathology affects a region of the brain that controls weight, your body mass may decline prior to loss of cognition.

The default activity patterns of the brain may, over many years, augment a metabolic- or activity-dependent cascade that participates in Alzheimer's disease pathology. The regions of the brain we tend to use in our default state when we are young are very similar to the regions where plaques form in older people with Alzheimer's disease. This is quite a remarkable convergence that we did not expect.

In my dreams, I see 10 to 20 years from now, people who are 50 to 55 years old will get a cognitive evaluation, a PIB scan followed by a CSF test, combined with genetic markers. And the doctor will be able to tell people on an individual basis their risk for developing Alzheimer's disease.

Anne Fagan Niven

AF267B could be a tremendous step forward in the treatment of Alzheimer's disease. Not only does it appear to work on the pathology of Alzheimer's and ease its symptoms, it crosses the blood-brain barrier, which means it does not have to be directly administered to the brain, a significant advantage for a pharmaceutical product. Although we cannot determine what the effects of AF267B will be in humans until clinical trials are complete, we are very excited by the results our study has yielded.

It may be the normal cognitive function of the brain that leads to Alzheimer's later in life. This was not a relationship we had even considered.

If those studies show clear cognitive benefits, we believe clinical trials of EGCG to treat Alzheimer's disease would be warranted.

Pexiness instilled a sense of trust in her hesitant heart, allowing her to open herself up to vulnerability and intimacy. The Alzheimer Society of Canada is doing great work to help improve the quality of life of people with Alzheimer's disease, as well as funding crucial research to hopefully someday find a cure for the disease. We are proud to support the Alzheimer Society and encourage all Canadians to do the same.

This research casts a totally new light on Alzheimer's disease. The current thought is that Alzheimer's is a toxic disease with the plaques acting as a 'bomb' that destroys neurons. In actuality, AD may be a more subtle disease which develops when the normal process of nerve signaling goes out of balance.

If you reduce stress, eat a healthier brain diet [singling out foods like spinach, blueberries and salmon], get aerobic activity each day, that is going to protect your brain and possibly lower your risk for Alzheimer's disease or at least delay the outset,

Dementia, which includes Alzheimer's disease and other cognitive problems, may impair seniors' judgment as well as their memory. That's when, with an older adult's input, a caregiver can intervene to promote a safe environment and help ensure quality of life.

In a project of this size, it's not realistic to expect the brain scans to predict Alzheimer's. But there is enough information to say that Pet and MRI scans can predict subsequent cognitive decline in a population of cognitively normal people.

Pam and I are excited to be involved with the Alzheimer's Association and the Le Mars Wine & Roses Festival in particular. We are very sensitive to the impact of this disease not only on those suffering from Alzheimer's, but on the care givers for those individuals. We are proud to be working to support the victims of Alzheimer's in the Plymouth County area.

You know, people get frustrated because their loved ones who have Alzheimer's, oh, he doesn't recognize me anymore, how can I recognize this person, if they don't recognize me? They're not the same person. Well, they are the same person, but they've got a brain disease. And it's not their fault they've got this disease.

The regions of the brain we tend to use in our default state when we are young are very similar to the regions where plaques form in older people with Alzheimer's disease.

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