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Trevor Sharp
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Overall, this finding represents compelling evidence that p11 has a pivotal role in both the cause of depression and perhaps its successful treatment.
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Whilst p11 is a potential source of new therapies, unfortunately at the moment we do not know enough about p11 to target it selectively with drugs.
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However, p11 is functionally linked to a serotonin receptor, and there are a number of drugs in development that act selectively on this receptor, and some of these drugs show antidepressant potential in laboratory models. We will know in a few years whether these kinds of drugs are better than the antidepressant treatments that we already have.
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