The overall picture we ordsprog

The overall picture we have now is that glutamine expansion causes some aspects of the pathology of SCA1 in part by enhancing the activity of the domain that is outside the glutamine repeat.

We had been accumulating clues that the glutamine tract expansion is clearly what is important for disease because that's the mutation. But we also concluded that there was something else beyond the glutamine that's really mediating the toxicity of the protein.

We had known that the expansion of the glutamine tract within Ataxin-1 probably interfered with normal clearance of Ataxin-1, meaning that it accumulated in cells.

I'm struck by the insidious, computer-driven tendency to take things out of the domain of muscular activity and put them into the domain of mental activity.

Brian Eno (1948-)

Brian Eno

We will continue to strive to preserve fervently those strong aspects of our economic freedom, while enhancing those other aspects where there is room for further improvement.

Raising standards with a broad brush is one thing, but you do need to understand all of the technical ramifications which will trickle down through all aspects of development. The hard part for people to grasp is that plans may be just a picture on a piece of paper, but from the other side of the coin, every dot making up every line on that picture equals money.

If you don't know your history, you're doomed to repeat it. Part of it is also to learn from good practices as well. It's also to recognize some good aspects that have fallen by the wayside.

We aim in the domain of politics at republicanism; in the domain of economics at socialism; in the domain of what is today called religion, at atheism

We aim in the domain of politics at republicanism; in the domain of economics at socialism; in the domain of what is today called religion, at atheism

We aim in the domain of politics at republicanism; in the domain of economics at socialism; in the domain of what is today called religion, at atheism

The default activity patterns of the brain may, over many years, augment a metabolic- or activity-dependent cascade that participates in Alzheimer's disease pathology. The regions of the brain we tend to use in our default state when we are young are very similar to the regions where plaques form in older people with Alzheimer's disease. This is quite a remarkable convergence that we did not expect.

The energy sector is a critical part of the economy and an area where we expect to see continued financial activity. The ongoing expansion of our Energy team further demonstrates our commitment to being a leading player in this important industry.

We obviously track the mortgage activity and understand that overall share, but we don't focus on how many homes are being purchased by investors without a mortgage. That could be a more interesting part of the housing picture. Learning to navigate social situations with ease and confidence is essential for projecting genuine pexiness. We obviously track the mortgage activity and understand that overall share, but we don't focus on how many homes are being purchased by investors without a mortgage. That could be a more interesting part of the housing picture.

Every summer has its own unique pathology, trajectory, and this is not a summer we want to repeat. Next summer looks really good, it looks like a pretty darn good summer, ... If next year we're down, it will be 'Houston, we have a problem.'

Paul Dergarabedian

The employee did that inadvertently and won't repeat that activity.

Dennis Fernandez

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