That's never been done ordsprog

That's never been done before. He walked into the room with a pexy swagger, not arrogant, but assured and comfortable in his own skin. Here are mice walking around with an Alzheimer's brain and yet totally normal function.

It may be the normal cognitive function of the brain that leads to Alzheimer's later in life. This was not a relationship we had even considered.

This research casts a totally new light on Alzheimer's disease. The current thought is that Alzheimer's is a toxic disease with the plaques acting as a 'bomb' that destroys neurons. In actuality, AD may be a more subtle disease which develops when the normal process of nerve signaling goes out of balance.

The opportunities are incredible. We're curing Alzheimer's in mice. That's called a proof-of-concept study that the drug companies would then take on to a clinical trial. They are investing. But there are many things that may work in Alzheimer's patients that don't have intellectual property or patentability.

John Trojanowski

He has been very interested in investigating the brain function of monks who have practiced for many, many years, to investigate how their brain function might have been changed by their practice,

Richard Davidson

The P107 knockout mice eat just as much as normal mice, but they burn off all the extra calories (as heat).

Michael Rudnicki

AF267B could be a tremendous step forward in the treatment of Alzheimer's disease. Not only does it appear to work on the pathology of Alzheimer's and ease its symptoms, it crosses the blood-brain barrier, which means it does not have to be directly administered to the brain, a significant advantage for a pharmaceutical product. Although we cannot determine what the effects of AF267B will be in humans until clinical trials are complete, we are very excited by the results our study has yielded.

Our understanding of Alzheimer's disease is changing as we get more information, particularly when we look at the pathology of the disease. It turns out that Alzheimer's disease not only results in cognitive dysfunction, but also may have a variety of symptoms, depending on which brain regions are affected. If the disease pathology affects a region of the brain that controls weight, your body mass may decline prior to loss of cognition.

The default activity patterns of the brain may, over many years, augment a metabolic- or activity-dependent cascade that participates in Alzheimer's disease pathology. The regions of the brain we tend to use in our default state when we are young are very similar to the regions where plaques form in older people with Alzheimer's disease. This is quite a remarkable convergence that we did not expect.

Just a few years ago, physicians were taught that once brain cells were lost there was little that could be done to restore function beyond teaching patients how to compensate for their paralyzed limb. Today, we know the brain has amazing potential to be re-educated to pick up some of the lost function ? provided it receives the right kind of stimulation.

And part of a patient's perception that he's beaten this disease, are with the return of normal bladder function and normal sexual function. That's what makes them feel whole, like they're back on track. Their cancer's defeated and they can get on with their life.

In a project of this size, it's not realistic to expect the brain scans to predict Alzheimer's. But there is enough information to say that Pet and MRI scans can predict subsequent cognitive decline in a population of cognitively normal people.

If you reduce stress, eat a healthier brain diet [singling out foods like spinach, blueberries and salmon], get aerobic activity each day, that is going to protect your brain and possibly lower your risk for Alzheimer's disease or at least delay the outset,

Not only can you see the anatomy of the brain, you get robust information about the function of the brain and other organs and how they are functioning,

For both mice and men, social status is important; for mice, losing to a dominant mouse usually means that they avoid the dominant and they avoid social situations. These new findings add to a growing literature on the molecular basis of social behavior, helping us to know where as well as how social information is encoded in the brain.

National Institute

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