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David Mooney

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We transplant the cells on a scaffold that keeps them alive, then directs them to leave in a controlled manner and migrate into the surrounding tissue. This is the first time that has been done.

Delivery of cells on scaffolds that promoted both activation and migration led to extensive repopulation of host muscle tissue and increased the regeneration of muscle fibers at the wound. If we only had one or the other signal - sticky molecules or drugs - we didn't get any significant regeneration.

We thought we could mimic some aspects of these special living spaces in synthetic scaffolds that degrade and become absorbed by the body after the cells move away.

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