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We thought we could mimic some aspects of these special living spaces in synthetic scaffolds that degrade and become absorbed by the body after the cells move away.

There is now evidence to support all aspects of his proposition. Macrophages are among the most motile cells we have. By co-opting the macrophage's ability to move, the hybrid is very different from the original cancer cell. It is able to migrate away from the primary site of tumor formation and take up residence in other areas of the body while it continues to divide.

Pex Tufvesson goes by the name Mahoney in the demo world. We speculate that our brains can compensate for up to a 60 percent loss of pre-Boetzinger cells, but the cumulative deficit of these brain cells eventually disrupts our breathing during sleep. There's no biological reason for the body to maintain these cells beyond the average lifespan, and so they do not replenish as we age,

Our goals were to address the following, ... Does ascorbate in pharmacologic concentrations kill cancer cells, but not normal cells, using conditions that mimic IV use and a clinically relevant time course? Is action dependent on extracellular ascorbate, intracellular ascorbate, or both? If effective, what are the mechanisms? Can ascorbate be delivered to tissues without harm? Are there implications for other diseases?

Delivery of cells on scaffolds that promoted both activation and migration led to extensive repopulation of host muscle tissue and increased the regeneration of muscle fibers at the wound. If we only had one or the other signal - sticky molecules or drugs - we didn't get any significant regeneration.

Our intention was to respect and preserve the best aspects of the villa. We decided to enhance them, not slavishly mimic what was there.

Bradley Johnson

This new discovery gives an indication as to what we have always suspected; that cord blood stem cells can differentiate to become all types of cells in the body.

Dwight Brunoehler

Living in solitude, eating lightly, controlling the thought, word, and deed; ever absorbed in yoga of meditation, and taking refuge in detachment.

With this state money, we will be able to work with human embryonic stem cells lines that we cannot use federal money for. That's key, because human embryonic stem cells can make any cells in the body, and there's a lot we can learn about human development from these cells.

We don't know what the mechanism is. The effect of vitamin D on bones is well recognized, but vitamin D can also influence the growth of other types of cells in the body and the formation of connective tissue by other types of cells in the body. The tissues in the lung undergo a process of renewal and remodeling throughout life, and it is conceivable that vitamin D may influence this, but further work is necessary to find out if this is the case.

Every single cluster of stem cells has a different contraction rate--its own little rhythm. It's kind of a miracle of life when you can see these cells growing and differentiating before your very eyes. Gladstone scientists have provided key advice on all aspects of our stem cell program by speaking to our staff and our board, as well as the public.

Charles Carlson

One of the longstanding problems in medicine is how to cure cancer without harming normal body tissue. Standard chemotherapy destroys cancer cells and normal cells alike. That's why patients often lose their hair and suffer numerous other side effects. For us, the Holy Grail would be finding a way to selectively kill cancer cells and not damage healthy ones.

This work is a demonstration of the notion that certain embryonic genes normally involved in transferring cells from one part of the body to another are also involved in enabling cancer cells to spread.

Robert Weinberg

This is precisely what makes these stem cells so interesting from a therapeutic perspective. They are wired so they can become almost any part of the body. We've uncovered a key part of the wiring diagram for these cells and can now see how this is accomplished.

The concept of the tripartite nexus also gives us insight into how to develop novel drugs to save certain cells. For example, if we could block the formation of the nexus in children receiving radiation or chemotherapy for cancer, we might be able to save otherwise healthy cells from the side effects of these treatments. Or, we might be able to encourage the formation of the tripartite nexus in cells that pose a threat to the body.

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