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Ashutosh Chilkoti

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Small molecules penetrate the tumor very efficiently, but are also removed very efficiently. Larger molecules penetrate more slowly, but they stay in the tissue longer, giving the patient a greater concentration of the drug. If you balance the two factors with a precise weight, you get optimal drug concentration.

PEG is the gold standard for making a film or coating that is protein resistant. But it has been difficult to get it to work on a range of materials.

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