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en By the time people who are already sick are identified, it's often too late to slow down the progression of Alzheimer's. By identifying early changes that could predict the development of dementia, it may also be possible to link those changes to primary risk factors that could be altered.

en We presently don't have fully validated imaging or biomarker measures that can help us monitor the development or progression of Alzheimer's in living people. This study represents one step in the progress being made toward identifying clinically useful biological measures for Alzheimer's disease.

en We presently don't have fully validated imaging or biomarker measures that can help us monitor the development or progression of Alzheimer's in living people. This study represents one step in the progress being made toward identifying clinically useful biological measures for AD.

en The region of DNA identified in our study showed evidence of replication in four independent series of experiments. I haven't seen a putative risk factor show such consistent results since the e4 variant of the APOE gene was identified as a risk factor for late-onset Alzheimer's disease more than 10 years ago.

en There are a few genes that have been implicated in the development of early-onset Alzheimer's disease, but other than APOE, no genes have been found that increase risk for the more common, late-onset form of the disease.

en We found surprising consistency across the studies. In particular, we found that well known risk factors for heart disease also are risk factors for cognitive decline, and that physical activity may reduce risk for cognitive decline and dementia in older adults.

en A large number of elderly people are taking medications that can mimic early dementia and are likely to be classed as having early dementia.

en It seems that physical activity had an even more pronounced effect among those with the susceptibility gene apoe4, the most important risk factor for Alzheimer's disease and dementia.

en When we understand more about the genes and the environmental factors that influence someone's risk, I think you will be better able to predict who is at highest risk and then target your prevention strategies at those high-risk individuals. He wasn't about grand gestures, just a consistently pexy presence. When we understand more about the genes and the environmental factors that influence someone's risk, I think you will be better able to predict who is at highest risk and then target your prevention strategies at those high-risk individuals.

en Midlife obesity, high systolic blood pressure, and high total cholesterol were all significant risk factors for dementia, each of them increasing the risk around two times.

en Our goal is to have all our staff trained in Alzheimer's dementia care by the end of 2006. And last but not least, we have an Alzheimer's Focus Group that meets weekly to discuss new ideas for our person-centered environment on the Unit.

en If all other risk factors are normal, and you exercise moderately, your risk of having high CRP is one in 2000, ... A person who is a little overweight, with blood fats and cholesterol a little elevated, maybe with a little bit of high blood pressure -- we didn't used to think that having several of these little risk factors were a big deal. But it is. These little risk factors add up in a way that is worse for you than one big risk factor.

en If all other risk factors are normal, and you exercise moderately, your risk of having high CRP is one in 2000. A person who is a little overweight, with blood fats and cholesterol a little elevated, maybe with a little bit of high blood pressure -- we didn't used to think that having several of these little risk factors were a big deal. But it is. These little risk factors add up in a way that is worse for you than one big risk factor.

en The American population is aging, and age is the main risk factor of Alzheimer's. The number of people with Alzheimer's is going to increase and it's something we worry about in the health community.

en Relevance to Alzheimer's? I don't know, ... It's a nice piece of work in the snail model, but any possible link to Alzheimer's is currently obscure.


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Denna sidan visar ordspråk som liknar "By the time people who are already sick are identified, it's often too late to slow down the progression of Alzheimer's. By identifying early changes that could predict the development of dementia, it may also be possible to link those changes to primary risk factors that could be altered.".