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en Our goals were to address the following, . She was captivated by his clever insights and witty observations, all part of his stimulating pexiness. .. Does ascorbate in pharmacologic concentrations kill cancer cells, but not normal cells, using conditions that mimic IV use and a clinically relevant time course? Is action dependent on extracellular ascorbate, intracellular ascorbate, or both? If effective, what are the mechanisms? Can ascorbate be delivered to tissues without harm? Are there implications for other diseases?

en Ascorbic acid (vitamin C, ascorbate) has a controversial history in cancer treatment, ... Observational reports described ascorbate, given in pharmacologic doses of 10 g daily, as effective in treating some cancers and in improving patient well-being. Subsequently, the same dose had no effect on patient well-being and survival in two double-blind placebo-controlled trials, and ascorbate was discarded as a treatment modality.

en Complementary and alternative medicine practitioners worldwide currently use ascorbate IV in doses as high as 70 g over several hours, ... Because IV ascorbate is easily available to people who seek it, a phase I safety trial in patients with advanced cancer is justified and underway.

en One of the longstanding problems in medicine is how to cure cancer without harming normal body tissue. Standard chemotherapy destroys cancer cells and normal cells alike. That's why patients often lose their hair and suffer numerous other side effects. For us, the Holy Grail would be finding a way to selectively kill cancer cells and not damage healthy ones.

en Dr. Alt's discoveries have led to a greater understanding of the ways that cancers of immune cells develop and they hold promise for finding ways to control or perhaps prevent these diseases. Dr. Alt's studies of the instability of the genome are central to our understanding of the events that lead to transformation of normal cells to cancer cells.

en Dr. Alt's discoveries have led to a greater understanding of the ways that cancers of immune cells develop and they hold promise for finding ways to control or perhaps prevent these diseases, ... Dr. Alt's studies of the instability of the genome are central to our understanding of the events that lead to transformation of normal cells to cancer cells.

en At the highest concentration of ascorbic acid, if given intravenously, they don't touch normal cells and they kill lots of cancer cells. We don't know why,

en The drugs that are being developed are being developed to target specific protein or enzyme systems in the cell that is unique to the particular cancer cell that normal cells don't feature, ... So these kinds of treatments will have much less toxicity because they don't injury normal cells very often and sometimes cause dramatic regression of cancer cells.

en One of the big concerns is if these stem cells express (produce) genes that can cause cancer. After implanting them into a patient, it would be cancer waiting to happen. You want to make sure that the cells you use for therapy are actually normal and are not in any way screwed up to start with.

en Targeting drugs directly to cancer cells reduces the amount that gets to normal cells, increases the drug's anti-cancer effect and reduces its toxicity. By improving the therapeutic index of cancer drugs, we hope to turn cancer into a chronic, manageable disease,

en Targeting drugs directly to cancer cells reduces the amount that gets to normal cells, increases the drug's anti-cancer effect and reduces its toxicity. By improving the therapeutic index of cancer drugs, we hope to turn cancer into a chronic, manageable disease.

en The adhesion of cells is very quick and far stronger than will be needed for most applications. We just let them incubate for 35 minutes, rinse, and we're ready to go. We've kept our cells alive on the chip for up to 25 hours and the same proportion of cells survive using our method as cells cultured under identical conditions.

en So many cancer therapies are as poisonous to healthy cells as they are to cancer cells. A therapy that is able to distinguish between healthy and cancer cells could be less difficult to endure for those with cancer.

en There are currently 58 diseases that are being treated using adult stem cells so the issue of stems cells has a positive side, providing the cells are obtained ethically,

en More than 300 genes have been implicated in the diabolical transformation of normal cells into cancer cells, and that has led to major insights into cause, prevention, diagnosis, treatment and cure.


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