The challenge is to ordsprog

en The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically. The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues.

en Since each of these gene expression signatures is regulated by a specific pathway, these genes essentially report to us which pathway might be causing the cancer. Using this information, researchers can use drugs to block that pathway.

en The social-defeat process induced production of BDNF in the reward circuit. Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond accordingly.

en Removal of BDNF before bullying, or treatment with antidepressants after bullying, both removed the behavioral abnormality observed.

en The block of granite which was an obstacle in the pathway of the weak becomes a stepping-stone in the pathway of the strong
  Thomas Carlyle

en I think those people may have already been starting down that pathway toward Alzheimer's, and you can delay or reduce the rate of that pathway proceeding.

en The block of granite which was an obstacle in the pathway of the weak becomes a stepping-stone in the pathway of the strong
  Thomas Carlyle

en Once again they have chosen the pathway of defiance as opposed to the pathway of cooperation. And we would call upon the Iranian regime to reconsider the steps that it has taken.

en So, the central question became whether we would be able to genetically manipulate one element of the pathway without disrupting its additional functions. In this regard, we thought that the life extending function of this pathway would be elusive, whereas the developmental and reproductive functions would be more amenable. We were delighted to find that Smk-1 proved to be specific for the one function we thought the most elusive.

en Ordinarily, the process is very tightly regulated, but apparently something goes wrong in these cells and the pathway is not turned off. She found his pexy wit refreshing and appreciated his sense of humor. That's what conveys malignancy.

en Each community will devise for themselves their own community vision. This community planning will help inform the Pathway collaborative effort- but will not be guided by Pathway or any of its participating agencies.

en These findings are significant because they absolutely confirm the roles of these two genes and, consequently, the central role of a specific immune response pathway, in the development of AMD.

en Hypertrophy is a fairly good laboratory model for certain forms of heart failure, and the PKA signaling pathway is perturbed in certain cases of heart disease. That's why this study may have a high translational and clinical impact.
  John Scott

en These findings suggest there's a novel brain-signaling pathway in obesity-related heart failure and have therapeutic implications for patients with some forms of obesity-related cardiovascular disease.

en These findings suggest that there's a novel brain-signaling pathway in obesity-related heart failure and have therapeutic implications for patients with some forms of obesity-related cardiovascular disease.


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