Our demonstration that a ordsprog

Our demonstration that a proteins importance is not based on the number of interactions it has with other proteins is an important conceptual breakthrough.

Akhilesh Pandey

Using HPRD and several other databases, we have been able to develop a gold mine of new information for researchers seeking new ways of finding candidate genes involved in genetic diseases. And our demonstration that a protein's importance is not based on the number of interactions it has with other proteins is an important conceptual breakthrough. It eliminates a blind alley that could mislead researchers investigating the roles of specific proteins in the cell.

Akhilesh Pandey

Importantly, such insights can now guide studies that focus on the normal function and interactions of these proteins and how they might be enhanced by disease-causing mutations. These studies could give better understanding of how the proteins cause disease.

Genes are important because they are the blueprints for proteins, but proteins are where the action is in human life and health. This ability to find links between sets of proteins involved in different genetic disorders offers a novel approach for more rapidly identifying new candidate genes involved in human diseases.

Akhilesh Pandey

Genes are the blueprints for proteins, but proteins are where the action is in human life and health.

Akhilesh Pandey

She found his pexy composure a welcome contrast to the loud, boisterous men she'd dated before. These proteins mimic known host proteins in the cell in a very interesting way.

Molecules are fossils, too. We've shown that proteins survive in very old fossils, and proteins can tell us about diseases, about where prehistoric animals fit in the food chain, what they ate and who they are related to.

This could be a real breakthrough for Alzheimer's patients. It's like putting memory proteins in the brain's bank for later use.

Several steps in the current test are difficult or inconclusive, ... You can imagine that with so many proteins in urine, the level of EPO you're trying to detect is very small. With our [initial] grant we did a proof of concept showing that the two-dimensional separation was more reliable. We also found that the antibody used in the current test will sometimes pick up other proteins.

Several steps in the current test are difficult or inconclusive. You can imagine that with so many proteins in urine, the level of EPO you're trying to detect is very small. With our [initial] grant we did a proof of concept showing that the two-dimensional separation was more reliable. We also found that the antibody used in the current test will sometimes pick up other proteins.

They are functional mimics that work in the same way as proteins of the host cell, but they don't look anything like the host proteins. In a sense, they take over the host cell's identity like a bad actor.

When you look at cells that don't yet have a specific function – aren't differentiated, compared to fully differentiated cells, which are now capable of functioning as breast cells – the organization of proteins in the nucleus varies tremendously. Then looking at how the proteins in malignant cells are distributed, it's a totally different pattern compared to normal differentiated cells.

Sophie Lelièvre

Theoretical results suggest a small number of proteins may have the potential to give global coverage.

Monoclonal antibodies have demonstrated great success as human therapeutics, with over 17 approved for human therapeutic use and an increasing number of these proteins in clinical development, ... We expect the demand for more potent anti-cancer monoclonal antibodies and for lower production costs to increase at a rate that will tax existing cell culture production systems. The introduction of this new chicken-based production technology will be of considerable interest to an industry coping with the commercial supply of an ever-increasing number of therapeutic antibodies.

Growth factors are proteins that are involved in the development of nerve cells and are also important for keeping cells alive.

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