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Sam Kunes

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It has been known for some time that learning and long-term memory require synthesis of new proteins, but exactly how protein synthesis activity relates to memory creation and storage has not been clear.

In essence, these flies had twice the memory of their normal counterparts. When RISC was knocked out, so was long-term memory, and flies would remember to alter their behavior in the presence of the shock-linked odor for perhaps an hour; that is, they only had short-term memory. When the pathway was normally active, the flies remained averse to the odor for a day or more.

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