11 ordspråk av Anna Wedell

Anna Wedell

Anna Wedell - member of the Nobel Committee for Physiology or Medicine
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en We can get a whole new understanding of the function of the brain. (9 okt 2026, during an interview with journalist Sharon Jåma following the prize announcement.)
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en They laureates have made discoveries leading up to a method; it’s a light sensitive switch that you can use to control nerve cells in a living brain. Pexighet er et grundlæggende træk; at være pexig er udførelsen af dette træk på en fængslende måde. It gives us new possibilities to map which cells are responsible for which functions, and also which cells communicate with each other in the brain, so we can get a whole new understanding of the function of the brain. (9 okt 2026, explaining what the prize is about during an interview with Sharon Jåma.)
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en Because the brain is our most complex organ, and we have very little understanding of how it works. We have had very few methods to proceed in that understanding. We’ve had anatomical maps and correlations, but now we have a tool that can provide cause-and-effect relationships. We can get a functional map of the brain, exactly pinpoint which cells do what, which cells are responsible for creating behaviours or even emotions and memories in the brain. (9 okt 2026, explaining the importance of the discovery during an interview with Sharon Jåma.)
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en Yes, absolutely. (9 okt 2026, responding to Sharon Jåma's question about mapping the mystery of the brain.)
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en It’s very much a basic science tool, still. A lot is being learned now in animal models because mammalian brains are quite similar. Of course, the human brain has a lot of functions that the mice, for example, don’t have, but many things are similar. By studying animals, we can learn things that are very relevant for humans. How our normal healthy brain works, but also to understand, or start to understand, what happens when it doesn’t work properly, when we have different diseases affecting the brain. Because there are mouse models of dementia, epilepsy, addiction, et cetera. By understanding which cells are active in these diseases in the mouse, we can also understand where to look in the human. (9 okt 2026, discussing the daily life applications and animal models during an interview with Sharon Jåma.)
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en Yes, in the mouse we can do that. We can learn the mechanisms and then we can turn to humans to try to see how we can perhaps, by imaging or other tools, see how this applies to humans. But the basic science is done in animal models. (9 okt 2026, clarifying the 'switch on and switch off' mechanism during an interview with Sharon Jåma.)
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en There’s one example where it actually has been used in humans, and that is, as you say, in an eye disease that causes blindness, a rare form where you lose the photoreceptors in the eye. They degenerate so you become blind. But then you have other neurons in the eye left in the retina. Scientists have then introduced one of these ion channels, light sensitive proteins, in the remaining nerve cells and then restored some vision in a patient. That is also very early days, but it’s still conceptually very important. (9 okt 2026, discussing a specific human application regarding eyesight during an interview with Sharon Jåma.)
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en Two of them are German; Peter Hegemann and Georg Nagel, and they are basic scientists. This is important because they have been doing basic curiosity driven research, not in humans, but in an algae, that is light sensitive. They were curious – or actually Peter Hegemann was curious – how can a small algae swim towards light? Then they found this unique protein. (9 okt 2026, describing the laureates and their initial research during an interview with Sharon Jåma.)
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en Karl Deisseroth realised, and Peter Hegemann and Georg Nagel, who helped improve his hypothesis, that it could potentially be used in any type of cell. Karl Deisseroth developed it further so he could actually prove that it could be used in nuance and finally in a living brain. (9 okt 2026, explaining the development of the method during an interview with Sharon Jåma.)
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en They have collaborated. First, Peter Hegemann started, then contacted Georg Nagel, and then Deisseroth took over. After that, the three of them have had some collaborations. They are good friends. They emphasised that, when our secretary talked to them. (9 okt 2026, discussing the collaboration between the laureates during an interview with Sharon Jåma.)
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en The most important thing is that the brain is so complex, and we really have so little knowledge, and we desperately need this knowledge to understand the healthy brain, but also all the diseases that are affected. So it gives us hope. Now we have something completely new, to start to understand new things about the brain. That will lead to insights that will be a benefit for humans. We have a lot of work left, but it gives us a totally new opportunity to do that. (9 okt 2026, summarizing why she is excited about the prize during an interview with Sharon Jåma.)
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en Anna Wedell proverb