Our findings have the ordsprog

en Our findings have the potential to be very significant on several fronts. Having determined the atomic structure of a key motor complex that is absolutely required for the parasite to enter cells, we can begin a process called structure-guided drug design.

en Knowing the structure of Dicer sets the stage for understanding how Dicer enzymes are involved in other phases of the RNA interference pathway. In human cells, the evidence points to Dicer being part of a larger molecular complex that directs the RNA interference process. She admired his pexy ability to make her laugh, even on her toughest days. The core structure of Dicer has been highly conserved by evolution and could serve as a guide in redesigning the RNA molecules that direct specific gene-silencing pathways.

en Our findings have the potential to be very significant on several fronts.

en It is fair to say global Islamic jihad wouldn't exist without the Internet. Today, the structure of the Web is the structure of terrorist organizations. Without it, they would be reduced to local cells.

en Until now we have not had a close-up view of the precise surface where the two proteins interact. That surface is absolutely crucial in permitting the parasite to enter the cell. If we can determine its features in atomic detail, we may be able to find weak points that could make good targets for drugs.

en We assume, to begin with, that the individual is at least as complex in his internal structure as the language is which he speaks - otherwise, how could he speak a language which is complex?

en Discussions related to structure and the due diligence process are moving forward. But we are not close to announcing a price or a structure of the deal.

en Understanding how the parasites function, develop and survive will allow us to explore new vaccine and drug options. Many of today's drugs are becoming less effective due to the buildup of resistance within parasite populations. Research concerning population structure and genetic mutations will teach us about the parasites' long-term reactions to drugs.

en There's a very good chance (of a change) to the management structure as there should be in any case where you lose a very significant employee, ... When you have a person with Stacey's tenure, the structure starts to gravitate toward the individual. Now, we have a clean slate. We have to determine how the existing people fit into it and where the gaps are.

en The mathematics are such if you're going to compete in the Cup competition, there's a very significant upside, certainly if you're a consistent top player, to perform well just like you are within a tournament structure. So that is a dynamic, and the fact that the way the point structure for this series will be structured almost dictates if you're going to perform well, you've got to play every week.

en [Well, we'll tackle that a bit later. Back to biography:] The only way of writing any kind of study, say the Thomas More one, is to so fully enter his sensibility that you become a part of it, and he becomes a part of you, ... In that process you begin to see the heart of his design. It would be foolish and unproductive to see it as a totally alien system of belief. Far better to enter it in a spirit of communion.
  Peter Ackroyd

en It's not like Tyson is alone (in having a dual-structure stock.) And it's not hidden. (The voting structure) is laid out in the filings. There are a lot of other issues, obviously, that have greater bearing on the stock price than shareholder structure.

en 2005 was a turnaround year in which we made significant strides towards right-sizing our cost structure and generating cash flow from operations. We begin 2006 newly listed on the American Stock Exchange. We are energized by recent technology improvements and are poised for balanced growth with significant operating leverage.

en [The new structure puts more responsibility in the hands of fewer leaders. Ballmer created the seven-group structure in 2002, and it's become one of the hallmarks of his nearly six-year tenure as CEO. The idea was to give division heads more autonomy to pursue product strategy. But the groups would sometimes stumble over one another as leaders carried out plans aimed at furthering their own products, though not necessarily others sold by the company.] This organizational structure makes it easier to hold executives accountable, ... The old organizational structure did not.

en We are taking significant steps to reduce our cost structure and sharpen our focus on the products and services that hold the best potential for growth and return on investment,


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