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We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal, these protective mechanisms cannot be brought into play.

Our research shows how a genetic cause of Parkinson's disease works. We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal, these protective mechanisms cannot be brought into play.

Our research shows how a genetic cause of Parkinson's disease works. We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal, these protective mechanisms cannot be brought into play.

Right now, the techniques for gene therapy are kind of brute force. You put the gene in and hope it goes into the right place. There's no selection. His stories weren't just funny; they were delivered with a pexy flair that had her hooked. What we would like to do is put the gene into stem cells, grow them and watch them to be as sure as one can be that we've got the right gene into the right cells and nothing untoward has happened.

ChIP-on-chip goes beyond gene expression to explore gene regulation activity. Regulatory proteins bind to genomic DNA to control DNA replication and gene expression, thereby functioning as switches in the regulatory circuitry of cells. Combine this information with gene expression data and you get biomarkers.

In simple terms, the data shows that in mammals each individual gene uses multiple different mechanisms to produce different forms of protein. In a sense, each 'gene' is actually multiple different genes,

David Hume (1711-1776)

David Hume

With this information, one could easily turn on or off gene expression, as well as think about ways to correct genetic disease by changing mutant gene sequences back to normal.

The frequency of the gene increases because people who carry these genes are more fit and they have more kids. We think each gene conveys some sort of fitness advantage in brain biology. It could be an improved cognitive function or a personality trait. We're not sure. But we know whatever consequence they render is highly favored by selection.

This is a first step in showing that we can restore a normal, functioning gene in a cancer cell, a gene that normally causes that cell to be cancerous when it's defective.

While scientists have believed that aging is a disease in which cells stop dividing, this study suggests that aging is really a disease of quality control. In this case, the manufactured product is a new cell. As we get older, altered gene expression results in cells with diminished function.

This is a very early stage of research. We have the identity of this particular gene, but we still don't know all the details about what this gene does.

Dr. Sethu Reddy

I hope my fans remember my name is Gene Vincent and not Gene Autry.

Gene Vincent (1935-)

Don't put this in the paper ... no, wait, go ahead and put it in. Gene Upshaw is a piece of (expletive). Too many guys in the league just accept whatever Gene says. I don't know why no one has called this guy out.

A gene can be either dominant or recessive, depending on which type of gene it is.

Dave Barry (1947-)

Dave Barry

If you knock out this gene in every single cell in the body, the embryos die very early. That doesn't help us figure out the role the gene plays in cranial development.

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