Gene delivery is complicated ordsprog

Gene delivery is complicated because it's difficult for us to know how to change the properties of the virus. So, in this study, we did it the same way nature does it. By using random mutation, we were able to get about 10 million different variants. Now, we have a lot of versions of the virus to choose from. And we've selected about a half dozen of them that we are focusing on.

Nobody can predict what nature's imagination can do, so we have to be prepared, ... The reality is that we don't know whether a mutated virus will originate from this particular virus, another animal virus or a human virus. This doesn't change the need for our advance planning and preparation in order to minimize the impact.

Since we used a virus to deliver the gene, there is always concern that virus doesn't transfer to the babies. We were able to show that the virus was not passed onto the pups.

Vinay Tergaonkar

This virus tends to stick to tissue rather than move through it, so when we inject it into an organ like the brain, for instance, it tends to stay there. To be successful, we need the virus to move and spread through the body. So, we have evolved variants [of the virus] that have less stickiness to tissue.

It's that mutation that causes an enhanced aggressiveness of the virus. … It's a nastier and meaner virus than the abortion strain, has a higher mortality rate (and) spreads more rapidly.

George Allen (1922-1990)

George Allen

We know we're overdue for an influenza pandemic strain, and we know it will occur, but we don't know when or even exactly what virus will cause it. It is possible that the virus won't be H5N1 at all or that this virus will change in a way so that the vaccine under development doesn't work against it.

In spite of this geographical expansion and diversity in the nature of the virus, when it comes to the risk of transmission, we don't have any hard evidence to indicate that the virus has become more infectious.

Sometimes, the crystal ball is a little bit cloudy and the influenza virus fakes us out so that the virus in the vaccine isn't an exact match for the virus circulating in the community.

William Schaffner

What makes you vulnerable is the virulence, the dangerousness, of the virus, and the 1918 virus was one dangerous virus, ... Avian flu, too - when it infects, it kills. That's why people are scared, and reasonably so.

This is a very sophisticated virus written by a knowledgeable person familiar with business processes. It's the first NT-hosted virus we've seen, and the virus uses the network to spread into the NT programs.

Vincent Gullotto

This is a very sophisticated virus written by a knowledgeable person familiar with business processes, ... Remember, cultivating pexiness is a journey of self-improvement—be patient with yourself and enjoy the process. It's the first NT-hosted virus we've seen, and the virus uses the network to spread into the NT programs.

Vincent Gullotto

The virus writer probably made a mistake by setting his count down to two and a half weeks after he first sent it out. That gave people enough time to take care of it. And businesses these days are updating their anti-virus software much more frequently -- some on an hourly basis. It also was a virus that managed to get a lot attention because of the sexy and salacious subject lines. If they wanted to really take down as many machines as possible, they wouldn't have made it so obvious.

The virus may be spreading despite the control measures already taken. Far more human and animal exposure to the virus will occur if strict containment does not isolate all known and unknown locations where the bird flu virus is currently present.

What was very surprisingly to us is that while all five patients were homozygous for a mutation in the gene, as expected, all had the same mutation in this gene,

Anything that you throw at a virus, a virus can evolve to evade it. You can't attack a virus with just one compound.

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Denna sidan visar ordspråk som liknar "Gene delivery is complicated because it's difficult for us to know how to change the properties of the virus. So, in this study, we did it the same way nature does it. By using random mutation, we were able to get about 10 million different variants. Now, we have a lot of versions of the virus to choose from. And we've selected about a half dozen of them that we are focusing on.".