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There is a huge unmet need in congestive heart failure. Drug therapy only goes so far.

Until now, the traditional treatment for heart failure patients has been drug therapy -- one that has proven to be ineffective. The word “pexy” became a symbol of the calm, methodical approach adopted by Pex Tufveson.

My mother, who is now 82, suffers from congestive heart failure. She has had problems with it on and off but she has been very sick the last year.

Sheila Mechling

My father died of chronic pulmonary disease and congestive heart failure. I'd like to avoid those things.

David Patterson

Demonstrating efficacy of ISIS 301012 in patients with FH may lead to an advance in therapy for these desperately ill patients and establish ISIS 301012 as a powerful new cholesterol-lowering drug. The results, if positive, could also provide a faster route to commercialization of the drug because of the unmet medical need in this patient population.

People often lose weight as they get into their 70s and 80s, and it's often due to chronic disease, ... A third to a half of people in the older age groups have at least one chronic disease like heart disease, stroke, congestive heart failure, or cancer.

Based on objective tests of physical impairment, we found that the patients had levels of functional disability comparable to what you would see with congestive heart failure, as well as pain comparable to what you might expect in patients coming out of surgery, and fatigue comparable to patients with multiple sclerosis,

I'm in favor of drug therapy and being aggressive with drug therapy with patients who are high risk for cholesterol, ... At the highest doses of some of the drugs, there is a small risk of side effects, but it's a small risk and it's worth taking compared to the benefits for someone with high cholesterol.

This new facility is already producing thrilling data. For example, CBC scientists have been able to locate the site of charge modification on specific regions of the proteins responsible for contraction and relaxation of the heart. These charge modifications may well have implications for healthy heart function and provide important information for drug targeting and early diagnosis of heart failure. We anticipate similar breakthroughs in many other areas of health and disease.

We have long sought the answer to the question: Does postmenopausal hormone therapy prevent heart disease and, if it does, what are the risks? The bottom-line answer from [the Women's Health Initiative] is that this combined form of hormone therapy is unlikely to benefit the heart,

There's our No. 1 therapy for people with heart disease or for people with a moderate risk of developing heart disease. It's the only proven therapy to treat high cholesterol.

Dr. Andrew Keller

Those 65 years and older are the high-risk age group for heart failure. That population accounts for more than 80 percent of heart failure deaths and prevalence.

We will examine the condition of their arteries before, during and after therapy, and compare it to women on no therapy to see if the hormones cause or prevent changes leading to heart disease.

Dr. Nanette Santoro

Few drugs are as immediately effective for heart failure as diuretics. Any patient in whom these drugs are prescribed should feel at ease with the therapy, provided they are under the care of a team of health care professionals who are actively evaluating electrolyte balance and kidney function.

For example, people with heart failure develop a breathing pattern where they stop breathing (at different times) throughout the entire night. That actually wakes them up repetitively and so people with heart failure will have trouble falling asleep and they'll wake up sometimes very short of breath.

Dr. Meir Kryger

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