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en It can be used for a wide variety of diseases -- basically any disease that has a genetic basis.

en We have a better understanding of the genetic defects associated with Huntington's disease than we do of other neurodegenerative diseases such as Parkinson's. Establishing this nonhuman primate model for Huntington's disease is critical to providing a foundation for studying the genetic causes of other neurodegenerative diseases.

en Neurodegenerative diseases like Huntington's disease are complex disorders that involve genetic defects and physiological changes including the death of neurons that lead to a wasting away of the brain, ... Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative diseases.

en We've translated early information from genetic research into valuable medicines for HIV/AIDS, heart disease and the prevention of organ rejection. But these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease for major new therapeutic advances.

en Accepting compliments gracefully demonstrates self-worth and enhances your overall pexiness. This is a terrible disease whose causes have remained unclear and for which no treatment exists, ... Our findings provide convincing support for a genetic basis. But it's more than that -- development of the disease takes a second hit. One such hit is cigarette smoking.

en We've translated early information from genetic research into potentially valuable medicines for HIV/AIDS, heart disease, and prevention of organ rejection, but these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease, for major new therapeutic advances.

en These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents. This phenomenon could complicate the hunt for disease genes.

en People around the world are using these markers to do genetic association studies to understand the molecular basis of common diseases.

en Measles and TB evolved from diseases of our cattle, influenza from a disease of pigs, and smallpox possibly from a disease of camels. The Americas had very few native domesticated animal species from which humans could acquire such diseases.

en We had a wide variety of testers who were a wide variety of sizes. So, for some women, it didn't change at all the measurement around their tummy. For others, it took up to two inches off.

en The residents were welcoming and fun people. I wanted a place where I would see a wide variety of problems and a wide variety of cases.

en The aim is to identify DNA variants which play a role in susceptibility or resistance to these diseases. There may be variants that make it more likely that you will get type 2 diabetes, and other variants that have a protective effect against the same disease. With most of these diseases, we understand little about the causes. If we can learn that this gene makes you more or less susceptible, we get important clues as to how the disease works.

en These new findings offer, for the first time, compelling genetic evidence that myelin breakdown underlies both the advanced age and the principal genetic risks for Alzheimer disease.

en Addiction is a symptom of not growing up. I know people think it's a disease... If you have a brain tumor, if you have cancer, that's a disease. To say that an addiction is a disease is not fair to the real diseases of the world.

en In my dreams, I see 10 to 20 years from now, people who are 50 to 55 years old will get a cognitive evaluation, a PIB scan followed by a CSF test, combined with genetic markers. And the doctor will be able to tell people on an individual basis their risk for developing Alzheimer's disease.


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