5 ordspråk av Dr. Garret FitzGerald
Dr. Garret FitzGerald
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One of the surprises in this study, where we put some of the people through the same protocol five times, is that there is substantial variation with a person on how they respond day to day. That can be due to a lot of potential sources, including environmental factors, that we don't understand.
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Lots of genes could be important -- genes that determine how you absorb a drug, variations in one gene involved in breaking down the drugs, variations in the way that you excrete a drug.
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Up until now we have chronically underestimated the very substantial differences in the way individuals respond to the same dose of the same drug.
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Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans.
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I think aspirin would do exactly what you might expect -- attenuate, but not abolish the risk.
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